Asetaminofen (Parasetamol) Sentezi

Amid bağı oluşumuyla bir analjezik sentezi

Organic Synthesis Advanced (University) 80 dak ~$18,00

Hedef

p-Aminofenolü asetik anhidrit ile asetilleyerek asetaminofen (parasetamol) sentezlemek ve amid bağı oluşumunu göstermek.

Arka Plan

Acetaminophen is one of the world's most widely used over-the-counter analgesics. Its synthesis involves the reaction of p-aminophenol with acetic anhydride to form an amide bond. The reaction is selective for the amine group over the phenol group under mild conditions.

Güvenlik Uyarıları

  • Acetic anhydride is corrosive and has a strong odor
  • p-Aminophenol can cause skin irritation
  • Do not consume the product
  • Work in a fume hood

Gerekli KKD

goggles gloves lab_coat

Malzemeler

  • p-Aminophenol (1.5 g)
  • Acetic anhydride (2 mL)
    Corrosive
  • Distilled water (100 mL)
    Ice-cold for crystallization
  • Acetone (10 mL)
    For recrystallization

Ekipman

250 mL Erlenmeyer flask Hot water bath Buchner funnel Filter flask Melting point apparatus Ice bath

Prosedür

1

Dissolve 1.5 g p-aminophenol in 15 mL distilled water in the Erlenmeyer flask. Warm gently if needed.

5 dak Handle p-aminophenol with gloves
2

Add 2 mL acetic anhydride to the solution. Stir vigorously for 10 minutes.

10 dak Fume hood — pungent vapors
3

Heat the mixture in a water bath at 70°C for 10 minutes to complete the reaction.

12 dak
4

Cool the mixture in an ice bath until crystals form.

15 dak
5

Collect crude product by vacuum filtration. Wash with cold water.

8 dak
6

Recrystallize from hot water or acetone/water mixture. Cool slowly for larger crystals.

15 dak
7

Collect purified crystals. Dry and determine melting point (pure: 168-170°C).

10 dak
8

Calculate percent yield.

5 dak

Beklenen Sonuçlar

White crystalline solid with melting point 167-170°C. Typical yield is 70-85%. The product should be pure white; discoloration indicates impurities from p-aminophenol oxidation.

Temizlik

Do not consume the product. Dispose of organic waste properly. Rinse all glassware.

Ayrıntılar

Kategori
Organic Synthesis
Zorluk
Advanced (University)
Süre
80 dak
Tahmini Maliyet
$18,00
Adımlar
8
Malzemeler
4

Daha Fazla Deney

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Frequently Asked Questions

What is the objective of Asetaminofen (Parasetamol) Sentezi?
p-Aminofenolü asetik anhidrit ile asetilleyerek asetaminofen (parasetamol) sentezlemek ve amid bağı oluşumunu göstermek.
How difficult is Asetaminofen (Parasetamol) Sentezi?
This experiment is rated as Advanced (University). It takes approximately 80 minutes to complete.
What safety precautions are needed for Asetaminofen (Parasetamol) Sentezi?
Key safety precautions include: Acetic anhydride is corrosive and has a strong odor; p-Aminophenol can cause skin irritation; Do not consume the product.
What materials are needed for Asetaminofen (Parasetamol) Sentezi?
The main materials required are: p-Aminophenol, Acetic anhydride, Distilled water, Acetone.
What results should I expect from Asetaminofen (Parasetamol) Sentezi?
White crystalline solid with melting point 167-170°C. Typical yield is 70-85%. The product should be pure white; discoloration indicates impurities from p-aminophenol oxidation.