Suzuki Coupling

ArBr + ArB(OH)2 → Ar–Ar + B(OH)3 + HBr

Genel Bakış

The Suzuki reaction couples an aryl halide with an aryl boronic acid using a palladium catalyst to form a biaryl product. This cross-coupling reaction proceeds through oxidative addition, transmetalation, and reductive elimination steps. Akira Suzuki shared the 2010 Nobel Prize for this work.

Günlük Örnek

The LCD screens in phones and TVs use organic molecules made by Suzuki coupling for their liquid crystal and OLED materials.

Endüstriyel Önemi

Suzuki coupling is one of the most widely used reactions in pharmaceutical manufacturing, producing drug molecules like losartan and several anti-cancer agents.

Özellikler

Tür
Organic
Geri Dönüşümlü
Hayır
Enerji
Ekzotermik
ΔH
-30,0 kJ/mol
Katalizör
Pd(PPh₃)₄

İlgili Reaksiyonlar

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Suzuki Coupling?
The balanced equation is: ArBr + ArB(OH)₂ → Ar–Ar + B(OH)₃ + HBr.
What type of reaction is Suzuki Coupling?
Suzuki Coupling is a organic reaction.
Is Suzuki Coupling exothermic or endothermic?
Suzuki Coupling is exothermic (releases energy). The enthalpy change (ΔH) is -30.0 kJ/mol.
What conditions are needed for Suzuki Coupling?
This reaction requires a catalyst (Pd(PPh₃)₄).