Suzuki Coupling

ArBr + ArB(OH)₂ → Ar–Ar + B(OH)₃ + HBr

Overview

The Suzuki reaction couples an aryl halide with an aryl boronic acid using a palladium catalyst to form a biaryl product. This cross-coupling reaction proceeds through oxidative addition, transmetalation, and reductive elimination steps. Akira Suzuki shared the 2010 Nobel Prize for this work.

Everyday Example

The LCD screens in phones and TVs use organic molecules made by Suzuki coupling for their liquid crystal and OLED materials.

Industrial Importance

Suzuki coupling is one of the most widely used reactions in pharmaceutical manufacturing, producing drug molecules like losartan and several anti-cancer agents.

Properties

Type: Organic
Reversible: No
Energy: Exothermic
ΔH: -30.0 kJ/mol
Catalyst: Pd(PPh₃)₄

Related Reactions

Aldol Condensation of Acetaldehyde Amide Formation (Acetic Acid + Ammonia) Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Bromination of Ethylene Buchwald-Hartwig Amination Cannizzaro Reaction of Formaldehyde Catalytic Hydrogenation of Ethylene Claisen Condensation (Ethyl Acetate) Condensation Polymerization (Nylon 6,6)

Frequently Asked Questions

What is the equation for Suzuki Coupling?

The balanced equation is: ArBr + ArB(OH)₂ → Ar–Ar + B(OH)₃ + HBr.

What type of reaction is Suzuki Coupling?

Suzuki Coupling is a organic reaction.

Is Suzuki Coupling exothermic or endothermic?

Suzuki Coupling is exothermic (releases energy). The enthalpy change (ΔH) is -30.0 kJ/mol.

What conditions are needed for Suzuki Coupling?

This reaction requires a catalyst (Pd(PPh₃)₄).