Aldol Condensation of Acetaldehyde

2CH₃CHO → CH₃CH(OH)CH₂CHO

Visão geral

Two molecules of acetaldehyde combine in a base-catalyzed aldol reaction to form 3-hydroxybutanal (aldol). The alpha-hydrogen of one molecule is abstracted by base to form an enolate, which attacks the carbonyl of the second molecule. Dehydration can follow to give an alpha,beta-unsaturated aldehyde (crotonaldehyde).

Exemplo do cotidiano

The aldol reaction is one of the most powerful carbon-carbon bond forming reactions in synthetic chemistry, used to build complex molecules.

Importância industrial

As reações aldólicas são utilizadas industrialmente para produzir 2-etil-hexanol (álcool plastificante), pentaeritritol (explosivos) e intermediários farmacêuticos.

Propriedades

Tipo: Organic
Reversível: Sim
Energia: Exotérmico
ΔH: -22,0 kJ/mol
Catalisador: NaOH (base catalyst)

Reações relacionadas

Swern Oxidation Oxidation of Secondary Alcohol to Ketone Claisen Condensation (Ethyl Acetate) Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Catalytic Hydrogenation of Ethylene Condensation Polymerization (Nylon 6,6) Cope Rearrangement Epoxidation of Alkenes (mCPBA)

Frequently Asked Questions

What is the equation for Aldol Condensation of Acetaldehyde?

The balanced equation is: 2CH₃CHO → CH₃CH(OH)CH₂CHO.

What type of reaction is Aldol Condensation of Acetaldehyde?

Aldol Condensation of Acetaldehyde is a organic reaction. It is reversible under certain conditions.

Is Aldol Condensation of Acetaldehyde exothermic or endothermic?

Aldol Condensation of Acetaldehyde is exothermic (releases energy). The enthalpy change (ΔH) is -22.0 kJ/mol.

What conditions are needed for Aldol Condensation of Acetaldehyde?

This reaction requires a catalyst (NaOH (base catalyst)).