Aldol Condensation of Acetaldehyde

2CH₃CHO → CH₃CH(OH)CH₂CHO

Visão geral

Two molecules of acetaldehyde combine in a base-catalyzed aldol reaction to form 3-hydroxybutanal (aldol). The alpha-hydrogen of one molecule is abstracted by base to form an enolate, which attacks the carbonyl of the second molecule. Dehydration can follow to give an alpha,beta-unsaturated aldehyde (crotonaldehyde).

Exemplo do cotidiano

The aldol reaction is one of the most powerful carbon-carbon bond forming reactions in synthetic chemistry, used to build complex molecules.

Importância industrial

As reações aldólicas são utilizadas industrialmente para produzir 2-etil-hexanol (álcool plastificante), pentaeritritol (explosivos) e intermediários farmacêuticos.

Propriedades

Tipo: Organic
Reversível: Sim
Energia: Exotérmico
ΔH: -22,0 kJ/mol
Catalisador: NaOH (base catalyst)

Reações relacionadas

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Catalytic Hydrogenation of Ethylene Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Aldol Condensation of Acetaldehyde?

The balanced equation is: 2CH₃CHO → CH₃CH(OH)CH₂CHO.

What type of reaction is Aldol Condensation of Acetaldehyde?

Aldol Condensation of Acetaldehyde is a organic reaction. It is reversible under certain conditions.

Is Aldol Condensation of Acetaldehyde exothermic or endothermic?

Aldol Condensation of Acetaldehyde is exothermic (releases energy). The enthalpy change (ΔH) is -22.0 kJ/mol.

What conditions are needed for Aldol Condensation of Acetaldehyde?

This reaction requires a catalyst (NaOH (base catalyst)).