Amide Formation (Acetic Acid + Ammonia)
CH3COOH + NH3 → CH3CONH2 + H2O
Visão geral
Acetic acid reacts with ammonia to first form ammonium acetate, which upon strong heating loses water to form acetamide. The amide bond (C-N) is the same linkage found in proteins (peptide bonds). Direct thermal dehydration is energy-intensive; industrial methods use acyl chlorides or coupling reagents.
Participantes
| Papel | Substância | Coeficiente | Estado |
|---|---|---|---|
| Reagente | Acetic Acid CH₃COOH | 1 | (l) |
| Reagente | Ammonia NH₃ | 1 | (g) |
| Produto | Water H₂O | 1 | (l) |
Exemplo do cotidiano
Every protein in your body is held together by amide (peptide) bonds, the same type of bond formed in this reaction.
Importância industrial
A formação de ligações amida é fundamental para a síntese de péptidos, o fabrico farmacêutico e a produção de nylon (poliamida).
Propriedades
- Tipo
- Organic
- Reversível
- Não
- Energia
- Exotérmico
- ΔH
- -25,0 kJ/mol
- Catalisador
- Heat
Reações relacionadas
Swern Oxidation
Oxidation of Secondary Alcohol to Ketone
Claisen Condensation (Ethyl Acetate)
Kolbe Electrolysis
Baeyer-Villiger Oxidation
Beckmann Rearrangement (Cyclohexanone Oxime)
Catalytic Hydrogenation of Ethylene
Condensation Polymerization (Nylon 6,6)
Cope Rearrangement
Epoxidation of Alkenes (mCPBA)
Frequently Asked Questions
What is the equation for Amide Formation (Acetic Acid + Ammonia)?
The balanced equation is: CH₃COOH + NH₃ → CH₃CONH₂ + H₂O.
What type of reaction is Amide Formation (Acetic Acid + Ammonia)?
Amide Formation (Acetic Acid + Ammonia) is a organic reaction.
Is Amide Formation (Acetic Acid + Ammonia) exothermic or endothermic?
Amide Formation (Acetic Acid + Ammonia) is exothermic (releases energy). The enthalpy change (ΔH) is -25.0 kJ/mol.
What conditions are needed for Amide Formation (Acetic Acid + Ammonia)?
This reaction requires a catalyst (Heat).