Cisplatin

Pt(NH₃)₂Cl₂

IUPAC: cis-Diamminedichloroplatinum(II)

CAS: 15663-27-1

Overview

Cisplatin is one of the most effective anticancer drugs, used to treat testicular, ovarian, bladder, and many other cancers. It crosslinks DNA to kill cancer cells.

Composition

Element Symbol Atoms Atomic Mass
Hydrogen H 6 1.0080
Nitrogen N 2 14.0070
Chlorine Cl 2 35.4500
Platinum Pt 1 195.0800

Elemental Composition

H
Hydrogen ×6
2.0%
N
Nitrogen ×2
9.3%
Cl
Chlorine ×2
23.6%
Pt
Platinum ×1
65.0%

Uses

  • • Cancer chemotherapy
  • • Testicular cancer
  • • Ovarian cancer
  • • Bladder cancer

Fun Facts

  • ✦ Cured Lance Armstrong's testicular cancer; cure rate for testicular cancer is now over 95% with cisplatin

Safety

  • ⚠ Kidney toxicity
  • ⚠ Nausea
  • ⚠ Hearing loss
  • ⚠ Nerve damage

Structure

SMILES

N.N.Cl[Pt]Cl

Properties

Type
inorganic
State
solid
Molar Mass
300.05 g/mol
Density
3.7400 g/cm³
Melting Point
270.0 °C
Solubility
2.5 g/L at 25°C

Molecular Descriptors

Exact Mass
298.9556
TPSA
2.0 Ų
H-Bond Donors
2
H-Bond Acceptors
2
Rotatable Bonds
0
Heavy Atoms
5
Complexity
7.0

Related Compounds

Aluminum Chloride

AlCl₃

Aluminum Nitride

AlN

Ammonium Persulfate

(NH₄)₂S₂O₈

Arsine

AsH₃

Barium Ferrite

BaFe₁₂O₁₉

Barium Titanate

BaTiO₃

Boron Nitride

BN

Boron Trichloride

BCl₃

Calcium Aluminate Cement

CaO·Al₂O₃

Calcium Carbide

CaC₂

Frequently Asked Questions

What is Cisplatin?
Cisplatin (Pt(NH₃)₂Cl₂) is a inorganic compound with the IUPAC name cis-Diamminedichloroplatinum(II).
What is the molecular weight of Cisplatin?
Cisplatin has a molar mass of 300.05 g/mol.
What state is Cisplatin at room temperature?
Cisplatin is a solid at room temperature.
Is Cisplatin organic or inorganic?
Cisplatin is classified as an inorganic compound.
What elements make up Cisplatin?
Cisplatin (Pt(NH₃)₂Cl₂) is composed of Hydrogen (H), Nitrogen (N), Chlorine (Cl), Platinum (Pt).