Chemistry Experiments

95 experiment protocols with step-by-step instructions

Difficulty	≤15 min	≤30 min	≤60 min	60+ min
Beginner (Middle School)	1	1	1	1
Intermediate (High School)	0	1	1	1
Advanced (University)	0	1	1	1
Professional (Lab)	0	0	0	1

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Aldol Condensation (Dibenzalacetone)

Synthesizing a UV-absorbing compound used in sunscreens

Synthesize dibenzalacetone via a crossed aldol condensation between benzaldehyde and acetone, demonstrating carbon-carbon bond formation.

Making the ester responsible for banana flavor

Synthesize isoamyl acetate (banana oil) via Fischer esterification of acetic acid and isoamyl alcohol, demonstrating how esters create fruit flavors.

Isolating a natural alkaloid using liquid-liquid extraction

Extract caffeine from tea leaves using liquid-liquid extraction with dichloromethane, demonstrating solvent extraction and natural product isolation.

Synthesizing an ester with a fruity aroma

Synthesize ethyl acetate (the aroma of nail polish remover) via Fischer esterification of acetic acid and ethanol, catalyzed by sulfuric …

Synthesizing an analgesic by amide bond formation

Synthesize acetaminophen (paracetamol) by the acetylation of p-aminophenol with acetic anhydride, demonstrating amide bond formation.

Making one of the world's most common drugs

Synthesize aspirin (acetylsalicylic acid) by acetylation of salicylic acid with acetic anhydride, and assess purity by melting point determination.