Grignard Reaction with Formaldehyde

CH3MgBr + HCHO → CH3CH2OH (after hydrolysis)

Visão geral

A Grignard reagent (methylmagnesium bromide) adds to formaldehyde, and after aqueous workup produces a primary alcohol. Grignard reagents are organomagnesium halides that act as powerful nucleophilic carbon sources. The reaction must be performed in anhydrous ether because Grignard reagents react violently with water.

Participantes

Papel Substância Coeficiente Estado
Reagente Formaldehyde CH₂O 1 (l)
Produto Ethanol C₂H₅OH 1 (l)

Exemplo do cotidiano

Victor Grignard won the 1912 Nobel Prize for this reaction, which revolutionized organic synthesis and is still one of the most taught reactions.

Importância industrial

As reações de Grignard são utilizadas na síntese de álcoois, ácidos carboxílicos e compostos orgânicos complexos. São fundamentais na indústria farmacêutica e agroquímica. Victor Grignard recebeu o Prémio Nobel da Química em 1912.

Propriedades

Tipo
Organic
Reversível
Não
Energia
Exotérmico
ΔH
-85,0 kJ/mol

Reações relacionadas

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Grignard Reaction with Formaldehyde?
The balanced equation is: CH₃MgBr + HCHO → CH₃CH₂OH (after hydrolysis).
What type of reaction is Grignard Reaction with Formaldehyde?
Grignard Reaction with Formaldehyde is a organic reaction.
Is Grignard Reaction with Formaldehyde exothermic or endothermic?
Grignard Reaction with Formaldehyde is exothermic (releases energy). The enthalpy change (ΔH) is -85.0 kJ/mol.