Suzuki Coupling

ArBr + ArB(OH)₂ → Ar–Ar + B(OH)₃ + HBr

Visão geral

The Suzuki reaction couples an aryl halide with an aryl boronic acid using a palladium catalyst to form a biaryl product. This cross-coupling reaction proceeds through oxidative addition, transmetalation, and reductive elimination steps. Akira Suzuki shared the 2010 Nobel Prize for this work.

Exemplo do cotidiano

The LCD screens in phones and TVs use organic molecules made by Suzuki coupling for their liquid crystal and OLED materials.

Importância industrial

O acoplamento de Suzuki é uma das reações mais utilizadas na indústria farmacêutica, produzindo moléculas como o losartan e vários agentes anticancerígenos.

Propriedades

Tipo: Organic
Reversível: Não
Energia: Exotérmico
ΔH: -30,0 kJ/mol
Catalisador: Pd(PPh₃)₄

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Frequently Asked Questions

What is the equation for Suzuki Coupling?

The balanced equation is: ArBr + ArB(OH)₂ → Ar–Ar + B(OH)₃ + HBr.

What type of reaction is Suzuki Coupling?

Suzuki Coupling is a organic reaction.

Is Suzuki Coupling exothermic or endothermic?

Suzuki Coupling is exothermic (releases energy). The enthalpy change (ΔH) is -30.0 kJ/mol.

What conditions are needed for Suzuki Coupling?

This reaction requires a catalyst (Pd(PPh₃)₄).