Suzuki Coupling
ArBr + ArB(OH)2 → Ar–Ar + B(OH)3 + HBr
概要
The Suzuki reaction couples an aryl halide with an aryl boronic acid using a palladium catalyst to form a biaryl product. This cross-coupling reaction proceeds through oxidative addition, transmetalation, and reductive elimination steps. Akira Suzuki shared the 2010 Nobel Prize for this work.
日常の例
The LCD screens in phones and TVs use organic molecules made by Suzuki coupling for their liquid crystal and OLED materials.
産業上の重要性
鈴木カップリングは医薬品製造で最も広く使用される反応の一つであり、ロサルタンや複数の抗がん剤の製造に使用される。
特性
- タイプ
- Organic
- 可逆的
- いいえ
- エネルギー
- 発熱性
- ΔH
- -30.0 kJ/mol
- 触媒
- Pd(PPh₃)₄
関連する反応
Swern Oxidation
Oxidation of Secondary Alcohol to Ketone
Claisen Condensation (Ethyl Acetate)
Kolbe Electrolysis
Baeyer-Villiger Oxidation
Beckmann Rearrangement (Cyclohexanone Oxime)
Catalytic Hydrogenation of Ethylene
Condensation Polymerization (Nylon 6,6)
Cope Rearrangement
Epoxidation of Alkenes (mCPBA)
Frequently Asked Questions
What is the equation for Suzuki Coupling?
The balanced equation is: ArBr + ArB(OH)₂ → Ar–Ar + B(OH)₃ + HBr.
What type of reaction is Suzuki Coupling?
Suzuki Coupling is a organic reaction.
Is Suzuki Coupling exothermic or endothermic?
Suzuki Coupling is exothermic (releases energy). The enthalpy change (ΔH) is -30.0 kJ/mol.
What conditions are needed for Suzuki Coupling?
This reaction requires a catalyst (Pd(PPh₃)₄).