Suzuki Coupling

ArBr + ArB(OH)2 → Ar–Ar + B(OH)3 + HBr

概要

The Suzuki reaction couples an aryl halide with an aryl boronic acid using a palladium catalyst to form a biaryl product. This cross-coupling reaction proceeds through oxidative addition, transmetalation, and reductive elimination steps. Akira Suzuki shared the 2010 Nobel Prize for this work.

日常の例

The LCD screens in phones and TVs use organic molecules made by Suzuki coupling for their liquid crystal and OLED materials.

産業上の重要性

鈴木カップリングは医薬品製造で最も広く使用される反応の一つであり、ロサルタンや複数の抗がん剤の製造に使用される。

特性

タイプ
Organic
可逆的
いいえ
エネルギー
発熱性
ΔH
-30.0 kJ/mol
触媒
Pd(PPh₃)₄

関連する反応

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Suzuki Coupling?
The balanced equation is: ArBr + ArB(OH)₂ → Ar–Ar + B(OH)₃ + HBr.
What type of reaction is Suzuki Coupling?
Suzuki Coupling is a organic reaction.
Is Suzuki Coupling exothermic or endothermic?
Suzuki Coupling is exothermic (releases energy). The enthalpy change (ΔH) is -30.0 kJ/mol.
What conditions are needed for Suzuki Coupling?
This reaction requires a catalyst (Pd(PPh₃)₄).