Claisen Condensation (Ethyl Acetate)

2CH3COOC2H5 → CH3COCH2COOC2H5 + C2H5OH

概述

Two molecules of ethyl acetate undergo base-catalyzed condensation to form ethyl acetoacetate (a beta-keto ester) and ethanol. The enolate of one ester molecule attacks the carbonyl of another, displacing ethoxide. This is the ester analogue of the aldol reaction.

参与者

角色 物质 系数 状态
产物 Ethanol C₂H₅OH 1 (l)

日常示例

Ethyl acetoacetate is a versatile synthetic building block used in the synthesis of vitamins, dyes, and pharmaceuticals.

工业重要性

克莱森缩合用于生产乙酰乙酸酯衍生物,用于制药、农药和聚酯合成。

属性

类型
Organic
可逆
是
能量
放热
ΔH
-10.0 kJ/mol
催化剂
Sodium ethoxide (NaOEt)

相关反应

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Catalytic Hydrogenation of Ethylene Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Claisen Condensation (Ethyl Acetate)?
The balanced equation is: 2CH₃COOC₂H₅ → CH₃COCH₂COOC₂H₅ + C₂H₅OH.
What type of reaction is Claisen Condensation (Ethyl Acetate)?
Claisen Condensation (Ethyl Acetate) is a organic reaction. It is reversible under certain conditions.
Is Claisen Condensation (Ethyl Acetate) exothermic or endothermic?
Claisen Condensation (Ethyl Acetate) is exothermic (releases energy). The enthalpy change (ΔH) is -10.0 kJ/mol.
What conditions are needed for Claisen Condensation (Ethyl Acetate)?
This reaction requires a catalyst (Sodium ethoxide (NaOEt)).