Baeyer-Villiger Oxidation

R2CO + RCO3H → R2CO2 (ester or lactone)

概述

A peracid oxidizes a ketone by inserting an oxygen atom between the carbonyl carbon and an adjacent carbon, converting the ketone to an ester or lactone. The more substituted group migrates preferentially (migratory aptitude). This reaction is named after Adolf von Baeyer and Victor Villiger who discovered it in 1899.

日常示例

The Baeyer-Villiger oxidation is used in the synthesis of caprolactone, the monomer for biodegradable polycaprolactone used in medical sutures.

工业重要性

环己酮通过拜耳-维立格氧化生产己内酯,支撑可降解塑料和医疗器械产业。

属性

类型
Organic
可逆
否
能量
放热
ΔH
-180.0 kJ/mol

相关反应

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Beckmann Rearrangement (Cyclohexanone Oxime) Catalytic Hydrogenation of Ethylene Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Baeyer-Villiger Oxidation?
The balanced equation is: R₂CO + RCO₃H → R₂CO₂ (ester or lactone).
What type of reaction is Baeyer-Villiger Oxidation?
Baeyer-Villiger Oxidation is a organic reaction.
Is Baeyer-Villiger Oxidation exothermic or endothermic?
Baeyer-Villiger Oxidation is exothermic (releases energy). The enthalpy change (ΔH) is -180.0 kJ/mol.