Amide Formation (Acetic Acid + Ammonia)

CH3COOH + NH3 → CH3CONH2 + H2O

概述

Acetic acid reacts with ammonia to first form ammonium acetate, which upon strong heating loses water to form acetamide. The amide bond (C-N) is the same linkage found in proteins (peptide bonds). Direct thermal dehydration is energy-intensive; industrial methods use acyl chlorides or coupling reagents.

参与者

角色 物质 系数 状态
反应物 Acetic Acid CH₃COOH 1 (l)
反应物 Ammonia NH₃ 1 (g)
产物 Water H₂O 1 (l)

日常示例

Every protein in your body is held together by amide (peptide) bonds, the same type of bond formed in this reaction.

工业重要性

酰胺键形成对多肽合成、药物制造以及尼龙(聚酰胺)生产至关重要。

属性

类型
Organic
可逆
否
能量
放热
ΔH
-25.0 kJ/mol
催化剂
Heat

相关反应

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Amide Formation (Acetic Acid + Ammonia)?
The balanced equation is: CH₃COOH + NH₃ → CH₃CONH₂ + H₂O.
What type of reaction is Amide Formation (Acetic Acid + Ammonia)?
Amide Formation (Acetic Acid + Ammonia) is a organic reaction.
Is Amide Formation (Acetic Acid + Ammonia) exothermic or endothermic?
Amide Formation (Acetic Acid + Ammonia) is exothermic (releases energy). The enthalpy change (ΔH) is -25.0 kJ/mol.
What conditions are needed for Amide Formation (Acetic Acid + Ammonia)?
This reaction requires a catalyst (Heat).