Michael Addition

CH2(COOC2H5)2 + CH2=CHCOCH3 → product

概述

A Michael donor (stabilized carbanion) adds to the beta-carbon of a Michael acceptor (alpha,beta-unsaturated carbonyl). This 1,4-conjugate addition forms a new carbon-carbon bond and is complementary to 1,2-addition. The Michael reaction is one of the most versatile C-C bond forming reactions.

日常示例

The Robinson annulation, combining Michael addition with aldol condensation, is used to build steroid ring systems in drug synthesis.

工业重要性

迈克尔加成是制药工业（构建药物骨架）、高分子化学（丙烯酸酯聚合）和天然产物全合成中不可或缺的关键反应之一。

属性

类型
Organic
可逆
是
能量
放热
ΔH
-25.0 kJ/mol
催化剂
Base (e.g., NaOEt)

相关反应

Swern Oxidation Oxidation of Secondary Alcohol to Ketone Claisen Condensation (Ethyl Acetate) Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Catalytic Hydrogenation of Ethylene Condensation Polymerization (Nylon 6,6) Cope Rearrangement Epoxidation of Alkenes (mCPBA)

Frequently Asked Questions

What is the equation for Michael Addition?
The balanced equation is: CH₂(COOC₂H₅)₂ + CH₂=CHCOCH₃ → product.
What type of reaction is Michael Addition?
Michael Addition is a organic reaction. It is reversible under certain conditions.
Is Michael Addition exothermic or endothermic?
Michael Addition is exothermic (releases energy). The enthalpy change (ΔH) is -25.0 kJ/mol.
What conditions are needed for Michael Addition?
This reaction requires a catalyst (Base (e.g., NaOEt)).