Обратное титрование антацидных таблеток

Измерение кислотонейтрализующей способности коммерческих антацидов

Titrations Intermediate (High School) 60 мин ~$12,00

Цель

Определить кислотонейтрализующую способность коммерческой антацидной таблетки методом обратного титрования.

Предпосылки

Direct titration of antacid is impractical because the active ingredients dissolve slowly. In a back titration, excess acid is added to the antacid, allowed to react fully, and the remaining unreacted acid is titrated with base. The difference reveals how much acid the antacid neutralized.

Предупреждения по безопасности

  • HCl and NaOH are corrosive
  • Wear safety goggles and gloves
  • Use caution with the hot plate

Требуемые СИЗ

goggles gloves lab_coat

Материалы

  • Antacid tablets (2 tablets)
    CaCO₃-based, like Tums
  • Hydrochloric acid (HCl) (200 mL)
    0.5M
  • Sodium hydroxide (NaOH) (100 mL)
    0.5M standardized
  • Phenolphthalein indicator (5 mL)
  • Distilled water (200 mL)

Оборудование

50 mL burette Burette stand and clamp 250 mL Erlenmeyer flask 25 mL pipette Mortar and pestle Analytical balance Hot plate

Процедура

1

Weigh the antacid tablet accurately on the analytical balance and record the mass.

3 мин
2

Crush the tablet into a fine powder using the mortar and pestle.

3 мин
3

Transfer the powder to the Erlenmeyer flask. Add exactly 50.0 mL of 0.5M HCl using the pipette.

3 мин Handle HCl carefully
4

Gently heat the mixture on the hot plate for 10 minutes to ensure complete reaction of the antacid.

12 мин Do not boil vigorously
5

Allow the solution to cool to room temperature.

5 мин
6

Add 2-3 drops of phenolphthalein indicator.

1 мин
7

Fill the burette with 0.5M NaOH. Titrate the excess HCl until a persistent pale pink color appears.

10 мин
8

Record the volume of NaOH used. Calculate moles of excess HCl, then moles neutralized by the antacid.

5 мин

Ожидаемые результаты

A typical CaCO₃-based antacid tablet (500 mg) should neutralize approximately 10 mmol of HCl. The mass of CaCO₃ calculated should approximate the labeled amount on the package.

Уборка

Neutralize all waste solutions before disposal. Rinse glassware thoroughly. Clean the mortar and pestle.

Frequently Asked Questions

What is the objective of Обратное титрование антацидных таблеток?
Определить кислотонейтрализующую способность коммерческой антацидной таблетки методом обратного титрования.
How difficult is Обратное титрование антацидных таблеток?
This experiment is rated as Intermediate (High School). It takes approximately 60 minutes to complete.
What safety precautions are needed for Обратное титрование антацидных таблеток?
Key safety precautions include: HCl and NaOH are corrosive; Wear safety goggles and gloves; Use caution with the hot plate.
What materials are needed for Обратное титрование антацидных таблеток?
The main materials required are: Antacid tablets, Hydrochloric acid (HCl), Sodium hydroxide (NaOH), Phenolphthalein indicator, Distilled water.
What results should I expect from Обратное титрование антацидных таблеток?
A typical CaCO₃-based antacid tablet (500 mg) should neutralize approximately 10 mmol of HCl. The mass of CaCO₃ calculated should approximate the labeled amount on the package.