Aldol Condensation of Acetaldehyde

2CH3CHO → CH3CH(OH)CH2CHO

概述

Two molecules of acetaldehyde combine in a base-catalyzed aldol reaction to form 3-hydroxybutanal (aldol). The alpha-hydrogen of one molecule is abstracted by base to form an enolate, which attacks the carbonyl of the second molecule. Dehydration can follow to give an alpha,beta-unsaturated aldehyde (crotonaldehyde).

日常示例

The aldol reaction is one of the most powerful carbon-carbon bond forming reactions in synthetic chemistry, used to build complex molecules.

工业重要性

羟醛反应工业上用于生产2-乙基己醇(增塑剂醇)、季戊四醇(炸药)以及医药中间体。

属性

类型
Organic
可逆
是
能量
放热
ΔH
-22.0 kJ/mol
催化剂
NaOH (base catalyst)

相关反应

Swern Oxidation Oxidation of Secondary Alcohol to Ketone Claisen Condensation (Ethyl Acetate) Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Catalytic Hydrogenation of Ethylene Condensation Polymerization (Nylon 6,6) Cope Rearrangement Epoxidation of Alkenes (mCPBA)

Frequently Asked Questions

What is the equation for Aldol Condensation of Acetaldehyde?
The balanced equation is: 2CH₃CHO → CH₃CH(OH)CH₂CHO.
What type of reaction is Aldol Condensation of Acetaldehyde?
Aldol Condensation of Acetaldehyde is a organic reaction. It is reversible under certain conditions.
Is Aldol Condensation of Acetaldehyde exothermic or endothermic?
Aldol Condensation of Acetaldehyde is exothermic (releases energy). The enthalpy change (ΔH) is -22.0 kJ/mol.
What conditions are needed for Aldol Condensation of Acetaldehyde?
This reaction requires a catalyst (NaOH (base catalyst)).