Wittig Reaction

Ph3P=CHR + R'CHO → R'CH=CHR + Ph3P=O

概述

A phosphorus ylide (Wittig reagent) reacts with an aldehyde or ketone to form an alkene and triphenylphosphine oxide. This reaction specifically converts C=O to C=C, making it invaluable for alkene synthesis with precise double bond placement. Georg Wittig won the 1979 Nobel Prize for this reaction.

日常示例

Vitamin A and beta-carotene are synthesized industrially using Wittig reactions to build their polyene chains with correct geometry.

工业重要性

维蒂希反应用于工业合成维生素A、β-胡萝卜素和其他含双键天然产物，是制药和精细化学品生产的重要方法。

属性

类型
Organic
可逆
否
能量
放热
ΔH
-90.0 kJ/mol

相关反应

Swern Oxidation Oxidation of Secondary Alcohol to Ketone Claisen Condensation (Ethyl Acetate) Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Catalytic Hydrogenation of Ethylene Condensation Polymerization (Nylon 6,6) Cope Rearrangement Epoxidation of Alkenes (mCPBA)

Frequently Asked Questions

What is the equation for Wittig Reaction?
The balanced equation is: Ph₃P=CHR + R'CHO → R'CH=CHR + Ph₃P=O.
What type of reaction is Wittig Reaction?
Wittig Reaction is a organic reaction.
Is Wittig Reaction exothermic or endothermic?
Wittig Reaction is exothermic (releases energy). The enthalpy change (ΔH) is -90.0 kJ/mol.