Suzuki Coupling

ArBr + ArB(OH)2 → Ar–Ar + B(OH)3 + HBr

概述

The Suzuki reaction couples an aryl halide with an aryl boronic acid using a palladium catalyst to form a biaryl product. This cross-coupling reaction proceeds through oxidative addition, transmetalation, and reductive elimination steps. Akira Suzuki shared the 2010 Nobel Prize for this work.

日常示例

The LCD screens in phones and TVs use organic molecules made by Suzuki coupling for their liquid crystal and OLED materials.

工业重要性

铃木偶联是制药工业中合成联苯类药物骨架（如氯沙坦、奈韦拉平）和有机电子材料的最重要方法之一。

属性

类型
Organic
可逆
否
能量
放热
ΔH
-30.0 kJ/mol
催化剂
Pd(PPh₃)₄

相关反应

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Suzuki Coupling?
The balanced equation is: ArBr + ArB(OH)₂ → Ar–Ar + B(OH)₃ + HBr.
What type of reaction is Suzuki Coupling?
Suzuki Coupling is a organic reaction.
Is Suzuki Coupling exothermic or endothermic?
Suzuki Coupling is exothermic (releases energy). The enthalpy change (ΔH) is -30.0 kJ/mol.
What conditions are needed for Suzuki Coupling?
This reaction requires a catalyst (Pd(PPh₃)₄).