Grignard Reaction with Formaldehyde

CH₃MgBr + HCHO → CH₃CH₂OH (after hydrolysis)

Tổng quan

A Grignard reagent (methylmagnesium bromide) adds to formaldehyde, and after aqueous workup produces a primary alcohol. Grignard reagents are organomagnesium halides that act as powerful nucleophilic carbon sources. The reaction must be performed in anhydrous ether because Grignard reagents react violently with water.

Người tham gia

Vai trò	Chất	Hệ số	Trạng thái
Chất phản ứng	Formaldehyde CH₂O	1	(l)
Sản phẩm	Ethanol C₂H₅OH	1	(l)

Ví dụ thực tế

Victor Grignard won the 1912 Nobel Prize for this reaction, which revolutionized organic synthesis and is still one of the most taught reactions.

Tầm quan trọng công nghiệp

Grignard reactions are used to synthesize alcohols, carboxylic acids, and complex molecules in pharmaceutical manufacturing.

Tính chất

Loại: Organic
Thuận nghịch: Không
Năng lượng: Tỏa nhiệt
ΔH: -85,0 kJ/mol

Phản ứng liên quan

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Grignard Reaction with Formaldehyde?

The balanced equation is: CH₃MgBr + HCHO → CH₃CH₂OH (after hydrolysis).

What type of reaction is Grignard Reaction with Formaldehyde?

Grignard Reaction with Formaldehyde is a organic reaction.

Is Grignard Reaction with Formaldehyde exothermic or endothermic?

Grignard Reaction with Formaldehyde is exothermic (releases energy). The enthalpy change (ΔH) is -85.0 kJ/mol.