Wittig Reaction

Ph₃P=CHR + R'CHO → R'CH=CHR + Ph₃P=O

Tổng quan

A phosphorus ylide (Wittig reagent) reacts with an aldehyde or ketone to form an alkene and triphenylphosphine oxide. This reaction specifically converts C=O to C=C, making it invaluable for alkene synthesis with precise double bond placement. Georg Wittig won the 1979 Nobel Prize for this reaction.

Ví dụ thực tế

Vitamin A and beta-carotene are synthesized industrially using Wittig reactions to build their polyene chains with correct geometry.

Tầm quan trọng công nghiệp

The Wittig reaction is used to synthesize vitamin A, beta-carotene, prostaglandins, and numerous pharmaceutical intermediates on industrial scale.

Tính chất

Loại: Organic
Thuận nghịch: Không
Năng lượng: Tỏa nhiệt
ΔH: -90,0 kJ/mol

Phản ứng liên quan

Swern Oxidation Oxidation of Secondary Alcohol to Ketone Claisen Condensation (Ethyl Acetate) Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Catalytic Hydrogenation of Ethylene Condensation Polymerization (Nylon 6,6) Cope Rearrangement Epoxidation of Alkenes (mCPBA)

Frequently Asked Questions

What is the equation for Wittig Reaction?

The balanced equation is: Ph₃P=CHR + R'CHO → R'CH=CHR + Ph₃P=O.

What type of reaction is Wittig Reaction?

Wittig Reaction is a organic reaction.

Is Wittig Reaction exothermic or endothermic?

Wittig Reaction is exothermic (releases energy). The enthalpy change (ΔH) is -90.0 kJ/mol.