Williamson Ether Synthesis

C2H5ONa + CH3I → C2H5OCH3 + NaI

개요

Sodium ethoxide (an alkoxide) reacts with methyl iodide in an SN2 reaction to form ethyl methyl ether. This is the most general and reliable method for synthesizing asymmetric ethers. The alkoxide acts as the nucleophile, and a primary alkyl halide provides the best yields.

일상 속 예시

MTBE (methyl tert-butyl ether), once the most widely used gasoline additive, was produced by a variation of ether synthesis.

산업적 중요성

윌리엄슨 합성은 아니솔, 크라운 에터, 폴리에틸렌글리콜 유도체, 의약품 에터 결합 생산에 사용됩니다.

성질

유형
Organic
가역 반응
아니오
에너지
발열
ΔH
-90.0 kJ/mol

관련 반응

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Williamson Ether Synthesis?
The balanced equation is: C₂H₅ONa + CH₃I → C₂H₅OCH₃ + NaI.
What type of reaction is Williamson Ether Synthesis?
Williamson Ether Synthesis is a organic reaction.
Is Williamson Ether Synthesis exothermic or endothermic?
Williamson Ether Synthesis is exothermic (releases energy). The enthalpy change (ΔH) is -90.0 kJ/mol.