올레핀 복분해
2 R–CH=CH–R' ⇌ R–CH=CH–R + R'–CH=CH–R'
개요
Olefin metathesis exchanges substituents around carbon-carbon double bonds using a ruthenium or molybdenum carbene catalyst. The mechanism involves [2+2] cycloaddition to form a metallacyclobutane, followed by cycloreversion. Chauvin, Grubbs, and Schrock shared the 2005 Nobel Prize for this reaction.
일상 속 예시
Ring-closing metathesis is used to produce macrocyclic drug molecules like the hepatitis C drug simeprevir.
산업적 중요성
Shell의 SHOP 공정은 교차 복분해를 이용하여 세제용 알파-올레핀을 생산합니다. 복분해는 의약품 합성을 변혁하고 있습니다.
성질
- 유형
- 유기
- 가역 반응
- 예
- 에너지
- 발열
- ΔH
- -5.0 kJ/mol
- 촉매
- Grubbs catalyst (Ru-based)
자주 묻는 질문
What is the equation for 올레핀 복분해?
The balanced equation is: 2 R–CH=CH–R' ⇌ R–CH=CH–R + R'–CH=CH–R'.
What type of reaction is 올레핀 복분해?
올레핀 복분해 is a 유기 reaction. It is reversible under certain conditions.
Is 올레핀 복분해 exothermic or endothermic?
올레핀 복분해 is exothermic (releases energy). The enthalpy change (ΔH) is -5.0 kJ/mol.
What conditions are needed for 올레핀 복분해?
This reaction requires a catalyst (Grubbs catalyst (Ru-based)).