Amide Formation (Acetic Acid + Ammonia)

CH3COOH + NH3 → CH3CONH2 + H2O

개요

Acetic acid reacts with ammonia to first form ammonium acetate, which upon strong heating loses water to form acetamide. The amide bond (C-N) is the same linkage found in proteins (peptide bonds). Direct thermal dehydration is energy-intensive; industrial methods use acyl chlorides or coupling reagents.

참여 물질

역할 물질 계수 상태
반응물 Acetic Acid CH₃COOH 1 (l)
반응물 Ammonia NH₃ 1 (g)
생성물 Water H₂O 1 (l)

일상 속 예시

Every protein in your body is held together by amide (peptide) bonds, the same type of bond formed in this reaction.

산업적 중요성

아마이드 결합 형성은 펩타이드 합성, 의약품 제조, 나일론(폴리아마이드) 생산의 핵심입니다.

성질

유형
Organic
가역 반응
아니오
에너지
발열
ΔH
-25.0 kJ/mol
촉매
Heat

관련 반응

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Amide Formation (Acetic Acid + Ammonia)?
The balanced equation is: CH₃COOH + NH₃ → CH₃CONH₂ + H₂O.
What type of reaction is Amide Formation (Acetic Acid + Ammonia)?
Amide Formation (Acetic Acid + Ammonia) is a organic reaction.
Is Amide Formation (Acetic Acid + Ammonia) exothermic or endothermic?
Amide Formation (Acetic Acid + Ammonia) is exothermic (releases energy). The enthalpy change (ΔH) is -25.0 kJ/mol.
What conditions are needed for Amide Formation (Acetic Acid + Ammonia)?
This reaction requires a catalyst (Heat).