Claisen Condensation (Ethyl Acetate)

2CH3COOC2H5 → CH3COCH2COOC2H5 + C2H5OH

개요

Two molecules of ethyl acetate undergo base-catalyzed condensation to form ethyl acetoacetate (a beta-keto ester) and ethanol. The enolate of one ester molecule attacks the carbonyl of another, displacing ethoxide. This is the ester analogue of the aldol reaction.

참여 물질

역할 물질 계수 상태
생성물 Ethanol C₂H₅OH 1 (l)

일상 속 예시

Ethyl acetoacetate is a versatile synthetic building block used in the synthesis of vitamins, dyes, and pharmaceuticals.

산업적 중요성

클라이젠 축합은 의약품, 농약, 그리고 폴리에스터 합성을 위한 아세토아세테이트 유도체를 생산하는 데 사용됩니다.

성질

유형
Organic
가역 반응
예
에너지
발열
ΔH
-10.0 kJ/mol
촉매
Sodium ethoxide (NaOEt)

관련 반응

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Catalytic Hydrogenation of Ethylene Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Claisen Condensation (Ethyl Acetate)?
The balanced equation is: 2CH₃COOC₂H₅ → CH₃COCH₂COOC₂H₅ + C₂H₅OH.
What type of reaction is Claisen Condensation (Ethyl Acetate)?
Claisen Condensation (Ethyl Acetate) is a organic reaction. It is reversible under certain conditions.
Is Claisen Condensation (Ethyl Acetate) exothermic or endothermic?
Claisen Condensation (Ethyl Acetate) is exothermic (releases energy). The enthalpy change (ΔH) is -10.0 kJ/mol.
What conditions are needed for Claisen Condensation (Ethyl Acetate)?
This reaction requires a catalyst (Sodium ethoxide (NaOEt)).