Suzuki Coupling

ArBr + ArB(OH)2 → Ar–Ar + B(OH)3 + HBr

개요

The Suzuki reaction couples an aryl halide with an aryl boronic acid using a palladium catalyst to form a biaryl product. This cross-coupling reaction proceeds through oxidative addition, transmetalation, and reductive elimination steps. Akira Suzuki shared the 2010 Nobel Prize for this work.

일상 속 예시

The LCD screens in phones and TVs use organic molecules made by Suzuki coupling for their liquid crystal and OLED materials.

산업적 중요성

스즈키 짝지음은 의약품 제조에서 가장 널리 사용되는 반응 중 하나로, 로사르탄과 여러 항암제 같은 약물 분자를 생산합니다.

성질

유형
Organic
가역 반응
아니오
에너지
발열
ΔH
-30.0 kJ/mol
촉매
Pd(PPh₃)₄

관련 반응

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Claisen Condensation (Ethyl Acetate) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Suzuki Coupling?
The balanced equation is: ArBr + ArB(OH)₂ → Ar–Ar + B(OH)₃ + HBr.
What type of reaction is Suzuki Coupling?
Suzuki Coupling is a organic reaction.
Is Suzuki Coupling exothermic or endothermic?
Suzuki Coupling is exothermic (releases energy). The enthalpy change (ΔH) is -30.0 kJ/mol.
What conditions are needed for Suzuki Coupling?
This reaction requires a catalyst (Pd(PPh₃)₄).