Claisen Condensation (Ethyl Acetate)

2CH₃COOC₂H₅ → CH₃COCH₂COOC₂H₅ + C₂H₅OH

Descripción general

Two molecules of ethyl acetate undergo base-catalyzed condensation to form ethyl acetoacetate (a beta-keto ester) and ethanol. The enolate of one ester molecule attacks the carbonyl of another, displacing ethoxide. This is the ester analogue of the aldol reaction.

Participantes

Rol	Sustancia	Coeficiente	Estado
Producto	Ethanol C₂H₅OH	1	(l)

Ejemplo cotidiano

Ethyl acetoacetate is a versatile synthetic building block used in the synthesis of vitamins, dyes, and pharmaceuticals.

Importancia industrial

La condensación de Claisen se utiliza para producir derivados del acetoacetato para productos farmacéuticos, agroquímicos y síntesis de poliésteres.

Propiedades

Tipo: Organic
Reversible: Sí
Energía: Exotérmico
ΔH: -10,0 kJ/mol
Catalizador: Sodium ethoxide (NaOEt)

Reacciones relacionadas

Epoxidation of Alkenes (mCPBA) Swern Oxidation Oxidation of Secondary Alcohol to Ketone E2 Elimination (Dehydrohalogenation) Aldol Condensation of Acetaldehyde Kolbe Electrolysis Baeyer-Villiger Oxidation Beckmann Rearrangement (Cyclohexanone Oxime) Catalytic Hydrogenation of Ethylene Dehydration of Ethanol

Frequently Asked Questions

What is the equation for Claisen Condensation (Ethyl Acetate)?

The balanced equation is: 2CH₃COOC₂H₅ → CH₃COCH₂COOC₂H₅ + C₂H₅OH.

What type of reaction is Claisen Condensation (Ethyl Acetate)?

Claisen Condensation (Ethyl Acetate) is a organic reaction. It is reversible under certain conditions.

Is Claisen Condensation (Ethyl Acetate) exothermic or endothermic?

Claisen Condensation (Ethyl Acetate) is exothermic (releases energy). The enthalpy change (ΔH) is -10.0 kJ/mol.

What conditions are needed for Claisen Condensation (Ethyl Acetate)?

This reaction requires a catalyst (Sodium ethoxide (NaOEt)).